Comparative effects of zopiclone and loprazolam on psychomotor and physical performance in active individuals
Deutscher übersetzter Titel: | Vergleich der Auswirkungen von Zopiclon und Loprazolam auf die psychomotorische und koerperliche Leistungsfaehigkeit von koerperlich aktiven Personen |
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Autor: | Grobler, L.A.; Schwellnus, Martin P.; Trichard, C.; Calder, S.; Noakes, T.D.; Derman, W.E. |
Erschienen in: | Clinical journal of sport medicine |
Veröffentlicht: | 10 (2000), 2, S. 123-128, Lit. |
Format: | Literatur (SPOLIT) |
Publikationstyp: | Zeitschriftenartikel |
Medienart: | Gedruckte Ressource |
Sprache: | Englisch |
ISSN: | 1050-642X, 1536-3724 |
Schlagworte: | |
Online Zugang: | |
Erfassungsnummer: | PU199912406726 |
Quelle: | BISp |
Abstract des Autors
Objective: Sedative hypnotics are used by athletes to alleviate precompetition anxiety and insomnia. The effects of these agents on exercise tolerance have not been extensively researched. Design: To determine the effects of sedative hypnotics on psychomotor and physical performance, a double-blind, placebo- (P) controlled, cross-over designed trial investigated the effects of zopiclone (Z) and loprazolam (L) on performance in 12 athletes. Intervention: Subjects ingested either P, Z (7.5 mg), or L (2 mg) on three different occasions separated by a 1-week washout period. Eye-hand coordination tests, a 30-m sprint test, an agility test, and a graded treadmill run to exhaustion for determination of VO2max were performed 10 hours after drug administration. Results: Subjects reported a significantly greater hangover effect following ingestion of L (8/11 subjects) compared with ingestion of Z (3/11 subjects; p<0.01). A greater number of subjects felt alert after ingestion of P (9/11 subjects) and Z (9/11 subjects) compared with L (4/11 subjects; p<0.01). The results of the eye-hand coordination tests, the 30-m sprint, the T-test, the VO2max, and the time to exhaustion during the treadmill run were not significantly altered following the ingestion of P, Z, and L. There was a significant difference between the delta values for Z and L for the number of missed responses in the eye-hand coordination tests (p<0.02). Therefore, following the ingestion of L, subjects experienced a significant hangover effect and altered reaction time, whereas the ingestion of Z did not significantly impair either psychomotor or physical performance in the administered tests. Clinical Relevance: Investigate the extent of the effects of sedative hypnotics on exercise performances, enabling team physicians to prescribe such drugs to the athlete more effectively. Verf.-Referat