Comparison of topical and oral treatments for tinea gladiatorum
Deutscher übersetzter Titel: | Vergleich von topischen und oralen Therapien bei Tinea gladiatorum |
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Autor: | Kohl, T.D.; Martin, D.C.; Berger, M.S. |
Erschienen in: | Clinical journal of sport medicine |
Veröffentlicht: | 9 (1999), 3, S. 161-166, Lit. |
Format: | Literatur (SPOLIT) |
Publikationstyp: | Zeitschriftenartikel |
Medienart: | Gedruckte Ressource |
Sprache: | Englisch |
ISSN: | 1050-642X, 1536-3724 |
Schlagworte: | |
Online Zugang: | |
Erfassungsnummer: | PU199911402896 |
Quelle: | BISp |
Abstract des Autors
Objective: Little has been published regarding treatment guidelines for tinea gladiatorum in the competitive wresting population, where outbreaks are commonplace. This study compares the efficacy of a first-line topical treatment regimen and an oral treatment regimen. Design: A randomized, prospective, open-label pilot study was conducted during the 1997 to 1998 interscholastic wrestling season. Setting: Training rooms at two suburban high schools. Participants: Male high school wrestlers with culture-proven tinea corporis were included in the study. There were 22 wrestlers enrolled; 17 finished the study. Interventions: Wrestlers were randomized to receive either clotrimazole 1% cream applied twice daily or fluconazole 200 mg once weekly for a total treatment duration of 3 weeks. Main Outcome Measures: Symptom scores, lesion measurements, and fungal cultures were followed to assess treatment efficacy. Results: Eleven wrestlers received clotrimazole and six wrestlers finished the full course of fluconazole. The extrapolated time to 50% improvement in symptom scores was 11.9 days in the clotrimazole group and 10.1 days in the fluconazole group. The extrapolated time to 50% lesion reduction was 18.7 days in the clotrimazole group and 17.2 days in the fluconazole group. The extrapolated time to 50% culture eradication was 22.7 days in the clotrimazole group and 11.1 days in the fluconazole group. Conclusion: Both clotrimazole and fluconazole produce similar improvement in clinical parameters. Fluconazole showed arithmetically, but not statistically, superior culture eradication. Fluconazole in a weekly dosing schedule should be considered in the first-line treatment of tinea gladiatorum. Verf.-Referat