Abstract des Autors

In prevention action against AAS use by sportsmen exercising in local clubs the Sport Medicine Outpatients Clinic of the Institute of Sport offered to a group of anonymous body builders a free medical examination and full information about their state of health and about the negative consequences of AAS application. The subjects, using voluntarily AAS, trained for themselves and were not body building competitors. They were informed on potential adverse effects of AAS on their health and informed consent was obtained from all of the subjects. The study, without any involvement of drug application to the subjects, was approved by the Ethical Commission of the Institute of Sport. The aim of the present study was to estimate the diagnostic validity of high density lipoprotein-cholesterol, creatinine kinase and luteinizing hormone measured in blood serum, in 17 body builders currently taking AAS (on cycle) and in 13 body builders who stopped using the AAS (off cycle). As a result: The analysis of the three tests considered together gave some advantage by high sensitivity (94%). However, the specificity in this case was relatively low (54%). It seems that the three tests should be assessed as a first step for screening of AAS abuse. Verf.-Referat