Administration of a GABA-B agonist Baclofen before running to exhaustion in the rat: effects on performance and on some indicators of fatigue
Gespeichert in:
| Deutscher übersetzter Titel: | Verabreichung des GABA-B-Agonisten Baclofen vor erschoepfender Laufbandbelastung bei Ratten: Auswirkungen auf die Leistung und auf einige Merkmale der Ermuedung |
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| Autor: | Abdelmalki, A.; Merino, D.; Bonneau, D.; Bigard, A.X.; Guezennec, C.Y. |
| Erschienen in: | International journal of sports medicine |
| Veröffentlicht: | 18 (1997), 2, S. 75-78, Lit. |
| Format: | Literatur (SPOLIT) |
| Publikationstyp: | Zeitschriftenartikel |
| Medienart: | Gedruckte Ressource Elektronische Ressource (online) |
| Sprache: | Englisch |
| ISSN: | 0172-4622, 1439-3964 |
| DOI: | 10.1055/s-2007-972598 |
| Schlagworte: | |
| Online Zugang: | |
| Erfassungsnummer: | PU199703203184 |
| Quelle: | BISp |
Abstract des Autors
The present study was designed to examine the effects of administration of a GABAergic agonist (Baclofen) on run-time to exhaustion in trained and untrained rats, and on some indicators of fatigue. Run-time to exhaustion on a treadmill set at a speed of 25 m/min was significantly increased in both untrained and trained rats administered with baclofen one hour before the exercise. The animals who had run the longest time displayed the lowest concentrations of liver and muscle glycogen, and a decrease in plasma glucose concentrations. The results of this investigation suggest that fatigue during prolonged exercise can be influenced by pharmacological administration of a GABAergic agonist. Indicators of fatigue such as glycemia, liver and muscular glycogen are not the limiting factors of performance and central mechanisms play a key role at exhaustion. Verf.-Referat