Abstract des Autors

The metabolic, hormonal, enzymatic and exercise induced factors which are significant for synthesis and degradation of muscular protein are reported and the responsible mechanisms, so far as known, discussed. The influence of different muscle contraction forms, coordination and neuromotoric stimulation on protein and glycogen degradation rates by laboratory tests is demonstrated. Furthermore, it is explained why urea is a better marker of the enhanced gluconeogenesis in the carbohydrate remetabolization than of protein degradation. Moreover, the blood ammonia increase after exercise with intact liver function depends more on the activity of the myoadenylate deaminase in the purine nucleotide cycle and the state of energy charge than on the muscular aminoacid metabolization. A case report of a body builder on anabolics demonstrates that anabolics could not prevent the rhabdomyolysis during strenuous training sessions before a competition when carbohydrates and fluid intake were drastically reduced in order to define the muscle relief. Verf.-Referat