Serotonergic agonists and antagonists affect endurance performance in the rat
Deutscher übersetzter Titel: | Serotonin-Agonisten und -Antagonisten beeinflussen die Ausdauerleistung bei Ratten |
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Autor: | Bailey, S.P.; Davis, J.M.; Ahlborn, E.N. |
Erschienen in: | International journal of sports medicine |
Veröffentlicht: | 14 (1993), 6, S. 330-333, Lit. |
Format: | Literatur (SPOLIT) |
Publikationstyp: | Zeitschriftenartikel |
Medienart: | Gedruckte Ressource Elektronische Ressource (online) |
Sprache: | Englisch |
ISSN: | 0172-4622, 1439-3964 |
DOI: | 10.1055/s-2007-1021187 |
Schlagworte: | |
Online Zugang: | |
Erfassungsnummer: | PU199311068143 |
Quelle: | BISp |
Abstract
The purpose of this experiment was to examine the effects of administration of serotonergic (5-HT) agonist and antagonist drugs on run-time to exhaustion (RUN-EXH) in male and female rats. RUN-EXH was reduced (p<0.05) in a dose relaetd manner by increasing dosages of quipazine dimaleate (QD: general 5-HT agonist) (0-5 mg/kg i.p.) administered immediately prior to exercise treadmill running at 20 m/min and 5 grade). Conversely, RUN-EXH was increased (p<0.05) by the greatest dosage of LY 53,857 (LY: 5-HT-1c and 5-HT-2 antagonist) (1.5 mg/kg i.p.). Drug effects were similar in male and female rats. The negative effects of QD administration on RUN-EXH were not attenuated by administration of the peripherally restricted antagonist, xylamidine tosylate (up to 300 ug/kg i.p.). The results of this investigation indicated that fatigue during prolonged exercise can be influenced by direct pharmacological administration of a serotonergic agonist and antagonist and that the mechanisms underlying these effects are likely to be central (brain) in nature. Verf.-Referat