Altered cellular distribution of hexokinase in skeletal muscle after exercise

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Deutscher übersetzter Titel:Veraenderte zellulaere Verteilung der Hexokinase im Skelettmuskel nach Muskelarbeit
Autor:Van Houten, D.R.; Davis, J.M.; Meyers, D.M.; Durstine, J.L.
Erschienen in:International journal of sports medicine
Veröffentlicht:13 (1992), 5, S. 436-438, Lit.
Format: Literatur (SPOLIT)
Publikationstyp: Zeitschriftenartikel
Medienart: Gedruckte Ressource Elektronische Ressource (online)
Sprache:Englisch
ISSN:0172-4622, 1439-3964
DOI:10.1055/s-2007-1021294
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Erfassungsnummer:PU199211060213
Quelle:BISp

Abstract

The purpose of this study was to determine the effects of a single period of swim exercise to exhaustion on the cellular distribution of hexokinase in rat skeletal muscle. The gastrocnemius muscle from male rats exercised (n=16) to exhaustion or allowed to remain inactive (n=14) was analyzed for hexokinase activity (HK) in the whole muscle homogenate and the mitochondrial-rich fraction. Although exercise produced a slight, non-significant, increase in HK activity in the whole muscle homogenate (p<0.09), HK activity in the mitochondrial-rich fraction was significantly increased in the exercised muscle (p<0.02). This shift in the cellular distribution of HK is towards the more active mitochondrial bound form and indicates an enhanced regulation of HK activity during physical exercise. Verf.-Referat