Hydroxylysine excretion does not indicate collagen damage with downhill running in young men
Deutscher übersetzter Titel: | Die Hydroxilysinausscheidung ist kein Anzeichen fuer eine Kollagenschaedigung nach Bergablauf bei jungen Maennern |
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Autor: | Wheat, M.R.; McCoy, S.L.; Barton, E.D.; Starcher, B.M.; Schwane, J.A. |
Erschienen in: | International journal of sports medicine |
Veröffentlicht: | 10 (1989), 3, S. 155-160, Lit. |
Format: | Literatur (SPOLIT) |
Publikationstyp: | Zeitschriftenartikel |
Medienart: | Gedruckte Ressource Elektronische Ressource (online) |
Sprache: | Englisch |
ISSN: | 0172-4622, 1439-3964 |
DOI: | 10.1055/s-2007-1024892 |
Schlagworte: | |
Online Zugang: | |
Erfassungsnummer: | PU199205052789 |
Quelle: | BISp |
Abstract
The purpose of this study was to determine whether urinary excretion of hydroxylysine (HO-Lys) is increased following prolonged, predominantly downhill running. Such an increase would be evidence of exercise-induced collagen damage. Each of ten young men performed a treadmill running test to determine VO2peak (an approximation of VO2max) followed by 60 min of intermittent running on -10 slope. Total urine excreted from 48 h pre-exercise to 96 h post-exercise was collected in 8-h samples for measurement of HO-Lys. In addition, both urinary 3-methylhistidine (3-MeHis) excretion and serum creatine kinase (SCK) activity were measured as indicators of muscle tissue damage. In no sampling period was post-exercise HO-Lys excretion altered compared with pre-exercise (e.g., pre-exercise: 82.2+/-9.6 micro-mol/24 h, mean +/- SE; 51.0+/-3.7 micro-mol/g creatinine; post-exercise: 72.9+/-2.0 micro-mol/24 h; 47.0+/-1.5 micro-mol/g creatinine). SCK activity was increased (346) 24 h post-exercise, but not immediately, 48 h, or 72 h post-exercise. 3-MeHis excretion was not altered following exercise. There were no strong associations between HO-Lys excretion and either of the markers of muscle damage. We concluded that no evidence of exercise-induced collagen damage was provided by urinary HO-Lys excretion. Verf.-Referat