Criteria to indicate testosterone administration
Deutscher übersetzter Titel: | Kriterien zum Nachweis von Testosteroneinnahme |
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Autor: | Kicman, A.T.; Brooks, R.V.; Collyer, S.C.; Cowan, D.A.; Nanjee, M.N.; Southan, G.J.; Wheeler, M.J. |
Erschienen in: | British journal of sports medicine |
Veröffentlicht: | 24 (1990), 4, S. 253-264, Lit. |
Format: | Literatur (SPOLIT) |
Publikationstyp: | Zeitschriftenartikel |
Medienart: | Gedruckte Ressource |
Sprache: | Englisch |
ISSN: | 0306-3674, 1473-0480 |
Schlagworte: | |
Online Zugang: | |
Erfassungsnummer: | PU199112049174 |
Quelle: | BISp |
Abstract
A detection method for testosterone administration was developed using radioimmunoassay to measure the urinary ratios of testosterone (T) to epitestosterone (E) and to luteinizing hormone (LH). A comparative study of the effect on these ratios of a single intramuscular injection of testosterone heptanoate followed by stimulation with human chorionic gonadotrophin (HCG) in three normal men was undertaken. To allow immediate investigation, a commercially supplied epitestosterone antiserum was used. This study showed that both T/E and T/LH ratios could be used to detect testosterone administration, the latter also being an indicator of HCG use due to cross-reactivity with the LH antiserum. Subsequently, an epitestosterone antiserum of superior specificity was raised and used in a study to demonstrate the insignificant effect of exercise on these ratios. Finally, an intramuscular injection of a combined preparation of testosterone/epitestosterone heptanoates resulted in raised ratios of T/LH but not of T/E. This demonstrated the importance of the T/LH ratio in circumstances where the T/E ratio can be easily circumvented. Verf.-Referat