Effect of training and detraining on in vivo insulin sensitivity
Deutscher übersetzter Titel: | Auswirkung von Training und Trainingspause auf die Insulinempfindlichkeit in vivo |
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Autor: | Nagasawa, J.; Sato, Y.; Ishiko, T. |
Erschienen in: | International journal of sports medicine |
Veröffentlicht: | 11 (1990), 2, S. 107-110, Lit. |
Format: | Literatur (SPOLIT) |
Publikationstyp: | Zeitschriftenartikel |
Medienart: | Gedruckte Ressource Elektronische Ressource (online) |
Sprache: | Englisch |
ISSN: | 0172-4622, 1439-3964 |
DOI: | 10.1055/s-2007-1024772 |
Schlagworte: | |
Online Zugang: | |
Erfassungsnummer: | PU199110043708 |
Quelle: | BISp |
Abstract
Insulin sensitivity was determined in rats to clarify the effect of detraining at 1 (trained state), 2, 3, and 7 days (7 rats each) and 14 days (n = 8) after five weeks of voluntary training using euglycemic insulin clamp technique. The relationship between basal insulin and glucose shifted towards a decrease in metabolic insulin needs compared to untrained controls (n = 20). During the insulin clamp study, to maintain comparable plasma glucose and insulin levels in all groups, the glucose infusion rate had to be increased significantly to 9.92 +/- 1.12 mg/kg/min compared to control group (6.57 +/- 0.57). This improved sensitivity persisted for 2 days after training but was significantly lowered in the 7-days-after group. In summary, this study shows that training effect on insulin sensitivity can be determined after voluntary training in rat. This training effect lasted 2 days after training. Verf.-Referat