Doping control of testosterone and human chorionic gonadotrophin: a case study
Deutscher übersetzter Titel: | Dopingnachweis von Testosteron und menschlichem Choriongonadotropin: ein Fallbericht |
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Autor: | Boer, D. de; Jong, E.G. de; Rossum, J.M. van; Maes, R.A.A.; Thomas, C.M.G.; Segers, M.F.G. |
Erschienen in: | International journal of sports medicine |
Veröffentlicht: | 12 (1991), 1, S. 46-51, Lit. |
Format: | Literatur (SPOLIT) |
Publikationstyp: | Zeitschriftenartikel |
Medienart: | Gedruckte Ressource Elektronische Ressource (online) |
Sprache: | Englisch |
ISSN: | 0172-4622, 1439-3964 |
DOI: | 10.1055/s-2007-1024654 |
Schlagworte: | |
Online Zugang: | |
Erfassungsnummer: | PU199109048476 |
Quelle: | BISp |
Abstract
Doping control for testosterone and human Chorionic Gonadotrophin (hCG) requires special attention as a difference must be made between the endogenous and exogenous origin of both substances. The detection of exogenous testosterone is based on the ratio of testosterone- to epitestosterone-glucuronide (T/E) in urine. The problems with ratio are discussed. For hCG analysis in urine the utilization of sandwich-type hCG specific assays instead of hCG/hCGbeta competitive assays is recommended. A case study in which an athlete self-administered testosterone and hCG before a competition is described. The T/E ratio and hCG concentration in urine were followed during this period of self-administration. The results demonstrate the relevance of the T/E ratio and of the selected hCG assay. The ratio of testosterone to human Luteinizing Hormone (T/hLH) in serum also indicated the use of hormones. Although the athletes urine was negative for exogenous testosterone directly after competition, he would have been found positive for hCG. Verf.-Referat