Effects of long-endurance running on immune system parameters and lymphocyte function in experienced marathoners
Deutscher übersetzter Titel: | Auswirkungen von erschoepfender Ausdauerlaufbelastung auf Parameter des Immunsystems und der Lymphozytenfunktion bei erfahrenen Marathonlaeufern |
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Autor: | Niemann, D.C.; Berk, L.S.; Simpson-Westerberg, M.; Arabatzis, K.; Youngberg, S.; Tan, S.A.; Lee, J.W.; Eby, W.C. |
Erschienen in: | International journal of sports medicine |
Veröffentlicht: | 10 (1989), 5, S. 317-323, Lit. |
Format: | Literatur (SPOLIT) |
Publikationstyp: | Zeitschriftenartikel |
Medienart: | Gedruckte Ressource Elektronische Ressource (online) |
Sprache: | Englisch |
ISSN: | 0172-4622, 1439-3964 |
DOI: | 10.1055/s-2007-1024921 |
Schlagworte: | |
Online Zugang: | |
Erfassungsnummer: | PU199001041393 |
Quelle: | BISp |
Abstract
The extent and duration of changes in leukocyte subsets, lymphocyte subpopulations, spontaneous blastogenesis, cortisol, and catecholamines were measured in ten experienced marathoners, who ran 3 h to exhaustion in a laboratory setting. Blood samples were taken at baseline, 1 h of exercise, and 5 min, 1.5 h, 6 h, and 21 h of recovery. The 3-h endurance run was associated with significant leukocytosis, granulocytosis, neutrophilia, monocytosis, and eosinopenia during recovery. All of these parameters except for eosinophils returned to normal by 21 h of recovery. Total lymphocyte count increased 31 at 1 h of exercise, then decreased 19 at 1.5 h of recovery when compared with baseline values. T cell count showed no significant changes, but B cell lymphocytosis was measured at 5 min and 6 h of recovery. T helper/T suppressor ratio (H/S) was significantly elevated 39 at both 1.5 h and 21 h of recovery due to the decrease in number of T suppressor cells. Spontaneous blastogenesis was significantly increased 52 by 1 h of exercise and remained elevated throughout recovery. The increase in cortisol from baseline to 1.5 h of recovery correlated positively with the increase in both total leukocyte count (r = 0.78, P = 0.008) and granulocyte count (r = 0.81, P = 0.005). Our results suggest that exhaustive endurance exercise in marathon runners is associated with many significant perturbations in immune system paramaters, most of which return to normal levels at 21 h of recovery. Verf.-Referat