Suitability of cyproterone acetate in the treatment of osteoporosis associated with athletic amenorrhea

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Deutscher übersetzter Titel:Eignung von Cyproteronacetat zur Behandlung der in Verbindung mit Amenorrhoe auftretenden Osteoporose bei Sportlerinnen
Autor:Cree, C. de; Lewin, R.; Ostyn, M.
Erschienen in:International journal of sports medicine
Veröffentlicht:9 (1988), 3, S. 187-192, Lit.
Format: Literatur (SPOLIT)
Publikationstyp: Zeitschriftenartikel
Medienart: Gedruckte Ressource Elektronische Ressource (online)
Sprache:Englisch
ISSN:0172-4622, 1439-3964
DOI:10.1055/s-2007-1025002
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Erfassungsnummer:PU198807012469
Quelle:BISp

Abstract

The effectiveness of the antiandrogenic agent cyproterone acetate (CA) in its contraceptive form (2 mg CA + 50 micro-g ethinyl estradiol) in the treatment of osteoporosis associated with athletic amenorrhea was studied in seven high-performance athletes. Four women with similar characteristics served as controls. Their mean age was 21.9 years +/- 3.9. Training was started at a mean age of 14.0 years +/- 2.0. The mean training intensity expressed as kilometers run per week was 35 +/- 15. Mineral density was primarily affected by the hypoestrogenic status of these athletes (=22 pg/ml+/-8.8 in the midluteal phase). All participants showed low serum progesterone (=2.85 ng/ml+/-2.10) and LH profiles (=5.6 mlU/ml+/-0.8) during the midluteal phase. Cyproterone acetate was administered for 8 months to treat increased bone loss in seven women athletes. Vertebral density appeared to be increased with 9.5+/-2.45 (mean +/- SD) while cortical base mineral content measured at the radius was not significantly changed. Our results demonstrate that cyproterone acetate administered in combination with estrogens provides a suitable therapeutic agent in the management of osteoporosis due to a hypoestrogenic status. This treatment could substitute other contraceptive agents. Moreover, women with the most severe estrogen deficiency showed a more pronounced reaction to this therapy. Verf.-Referat