Abnormal ventilation during exercise in McArdles syndrome: modulation by substrate availability

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Deutscher übersetzter Titel:Abnorme Ventilation waehrend koerperlicher Belastung bei McArdle Syndrom: Beeinflussbarkeit durch Substratverfuegbarkeit
Autor:Haller, Ronald G.; Lewis, Steven F.
Erschienen in:Neurology
Veröffentlicht:36 (1986), S. 716-719, Lit.
Format: Literatur (SPOLIT)
Publikationstyp: Zeitschriftenartikel
Medienart: Gedruckte Ressource
Sprache:Englisch
ISSN:0028-3878, 1526-632X
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Erfassungsnummer:PU198807010446
Quelle:BISp

Abstract

We evaluated ventilation during cycle exercise in four men lacking myophosphorylase. In submaximal exercise of similar relative intensity, ventilation was higher relative to oxygen uptake in McArdle patients than in normal men. The exercise ventilatory response returned to normal after glucose infusion, by fasting to increase free fatty acid availability or by combining fasting and submaximal exercise. Excessive ventilation in exercise was potentiated by inhibiting lipolysis with nicotine acid. The excessive ventilatory effort and resultant respiratory alkalosis may contribute to exercise intolerance. Verf.-Referat