A promising novel therapy for achilles peritendinitis: double-blind comparison of glycosaminoglycan polysulfate and high-dose indomethacin
Deutscher übersetzter Titel: | Eine vielversprechende neue Therapie der Achilles-Peritendinitis: Doppelblindvergleich von Glukosaminoglykan-Polysulfat und hochdosiertem Indomethacin |
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Autor: | Sundqvist, H.; Forsskahl, B.; Kvist, M. |
Erschienen in: | International journal of sports medicine |
Veröffentlicht: | 8 (1987), 4, S. 298-303, Lit. |
Format: | Literatur (SPOLIT) |
Publikationstyp: | Zeitschriftenartikel |
Medienart: | Gedruckte Ressource |
Sprache: | Englisch |
ISSN: | 0172-4622, 1439-3964 |
Schlagworte: | |
Online Zugang: | |
Erfassungsnummer: | PU198801031148 |
Quelle: | BISp |
Abstract
In this double-blind trial in 60 recreational athletes suffering from Achilles peritendinitis, we compared the effect of local injections of glycosaminoglycan polysulfate (GAGPS) with oral indomethacin (IM) administered over a 2-week period. Orthotic devices were prescribed in 66 of the cases to control biomechanical errors. The results after 1-year follow-up showed that GAGPS had a good overall therapeutic effect on two-thirds of the patients compared to one-third of the IM treated. In the patients with symptoms lasting longer than 3 months, IM had an effect in only 12 while GAGPS was beneficial in 59. Twenty-five cases of nonresponders and relapses underwent a crossover treatment. Those who received IM in this second period did not benefit from this treatment while those who received GAGPS showed a moderate to good effect in 8/17 (47) after a 2-week follow-up. A different mode of action is suggested as an explanation of the encouraging results. Verf.-Referat