Alpha-2-adrenoreceptor density on intact platelets and adrenaline-induced platelet aggregation in endurance- and nonendurance-trained subjects
Deutscher übersetzter Titel: | Alpha-2-Adrenorezeptorendichte auf intakten Thrombozyten und Adrenalin-bedingte Thrombozytenaggregation bei ausdauertrainierten und nichtausdauertrainierten Personen |
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Autor: | Lehmann, M.; Hasler, K.; Bergdolt, E.; Keul, Joseph |
Erschienen in: | International journal of sports medicine |
Veröffentlicht: | 7 (1986), 3, S. 172-176, Lit. |
Format: | Literatur (SPOLIT) |
Publikationstyp: | Zeitschriftenartikel |
Medienart: | Gedruckte Ressource Elektronische Ressource (online) |
Sprache: | Englisch |
ISSN: | 0172-4622, 1439-3964 |
DOI: | 10.1055/s-2008-1025757 |
Schlagworte: | |
Online Zugang: | |
Erfassungsnummer: | PU198605026451 |
Quelle: | BISp |
Abstract
Alpha-2-adrenoreceptor density on intact platelets was evaluated in 17 sportsmen, 8 of whom were endurance-trained athletes. Receptor density was determined as being equivalent to 3H-Yohimbine, specifically bound on intact platelets. Adrenaline-induced aggregation of platelets in vitro was additionally ascertained. Bmax (maximal binding) and KD (dissociation constant) were significantly lower in endurance-trained athletes (148 fmol per 10(9) platelets, KD = 0.92 nmol) than in the nine nonendurance-trained individuals (284 fmol, KD = 1.79 nmol), amounting to 89 receptors per cell (endurance-trained subjects) and 171 (nonendurance-trained subjects). No significant change of receptor density or affinity was observed subsequent to exhaustive exercise in the group of eight endurance-trained individuals. Bmax values and oxygen uptake capacity correlated negatively (r = -0.78) and Bmax values and induced platelet aggregation in vitro positively (r = 0.79). Data may indicate a reduced sensitivity of platelets in endurance-trained subjects. Verf.-Referat