Abstract

34 untreated patients with essential hypertension, 17 Patients under treatment with beta-blockade, and 32 healthy controls were studied at loadless pedaling (WO) and at the work load eliciting a blood lactate concentration corresponding to 4 mmol/l (OBLA). At WO the treated patients had approximately the same systolic blood pressure (SBP) as the healthy controls, while the untreated patients had a higher SBP. At WOBLA the SBP was higher in the untreated patients than in both the treated patients and the healthy controls. On an individual basis it was found in the healthy controls and the untreated patients that the SBP at WOBLA showed a slight increase versus SBP at WO, whereas the difference in SBP between WOBLA and WO (exercise SBP increase) demonstrated an inverse relationship versus WO. It was suggested that for both healthy controls and untreated patients the exercise SBP depended on a basal level as depicted by WO and a further SBP increase due to the exercise load. The difference between the two groups was that the patients with untreated hypertension displayed their relationships at higher pressure levels indicating the presence of a hyperkinetic drive. The treated patients appeared to have a lower increase in SBP between WO and WOBLA, suggesting an unfavorable effect of the beta-blockade. Verf.-Referat