Abstract des Autors

Twenty male volunteers underwent short-term treadmill exercise with stepwise acceleration until exhaustion. Blood samples were analyzed before, and after exercise. The number of circulating white blood cells increased (81.6 increase) resulting in lymphocytosis (131 ) and a minor granulocytosis (56.5). The most pronounced increase was observed with B-lymphocytes (225) followed by T-lymphocytes (110) and monocytes (87). The serum levels of immunoreactive insulin (56 increase), glucagon (42), cortisol (62), and most pronounced, growth hormone (2340 ) rose substantially. The metabolic activityof circulating monocytes was slightly enhanced after exhaustive exercise: 2deoxyglucose uptake increased by 12.5, glucose oxidation via the pentose phosphate shunt rose by 13.5, whereas the anaerobic formation of lactate remained unchanged. Incubation of resting monocytes with insulin alone had thesame but more pronounced effects on glucose metabolism (34 and 36 increase, respectively). Under the same conditions, dexamethasone decreased glucose oxidation and the anaerobic glucolysis but had no influence on glucose uptake. Exercise as well as insulin and dexamethasone slightly depressed the phagocytotic activity of monocytes when incubated with opsonized zymosan particles. (gekürzt)